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Synthesis and properties of tocopherol‐containing polymeric vesicle systems
Author(s) -
Cho Iwhan,
Kim YoungDae
Publication year - 1997
Publication title -
macromolecular symposia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.257
H-Index - 76
eISSN - 1521-3900
pISSN - 1022-1360
DOI - 10.1002/masy.19971180182
Subject(s) - vesicle , chemistry , monomer , amphiphile , polymer chemistry , ammonium thiocyanate , ammonium chloride , thiocyanate , chloride , potassium thiocyanate , tocopherol , size exclusion chromatography , polymerization , organic chemistry , copolymer , membrane , nuclear chemistry , polymer , antioxidant , biochemistry , vitamin e , enzyme
Two different tocopherol‐containing amphiphilic monomers, [ [ (tocopheryloxy)‐carbonyl ]‐methyl ] [ 2‐(methacryloyloxy)ethyl ]dimethyl‐ammonium chloride(3a) and [[ (tocopheryloxy)penta(ethoxy)carbonyl ]methyl ]2‐(methacryloyloxy)ethyl]dimethylammonium chloride(3b), were synthesized and polymerized. The formation of polymeric closed vesicles having diameters ranging from 200 to 5200 Å was confirmed by electron micrographs, entrapment of [ 14 C]sucrose, permeability measurements and gel filtration. The polymeric vesicles showed reduced permeability and enhanced thermodynamic stability. Antioxidative activities were determined by the thiocyanate method confirming that polymeric tocopherols also exhibited significant activities.