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Bioconjugate polymer materials that control cell functions
Author(s) -
Imanishi Yukio,
Ito Yoshihiro
Publication year - 1997
Publication title -
macromolecular symposia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.257
H-Index - 76
eISSN - 1521-3900
pISSN - 1022-1360
DOI - 10.1002/masy.19971180177
Subject(s) - cell adhesion , adhesion , insulin , polymer , growth factor , juxtacrine signalling , bioconjugation , covalent bond , chemistry , materials science , cell , biophysics , nanotechnology , biochemistry , biology , paracrine signalling , receptor , organic chemistry , endocrinology
Several examples of controlling cell functions in serum‐free culture media containing immobilized growth factor are reported. First, the growth and adhesion of cultured STO cells was regulated by insulin conjugated with thermo‐responsive polymers. Second, a photo‐immobilization technique was applied to insulin immobilization, and the photo‐immobilized insulin accelerated the growth of CHO cells. Third, photo‐immobilized EGF affected the differentiation of PC‐12 cells. Finally, a patterned artificial juxtacrine stimulation of CHO cells by insulin covalently immobilized by photo‐lithography is discussed.