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Polymeric carriers of drugs for site‐specific therapy
Author(s) -
Ulbrich Karel,
Pechar Michal,
Strohalm Jiři,
Šubr Vladimír,
říhová Blanka
Publication year - 1997
Publication title -
macromolecular symposia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.257
H-Index - 76
eISSN - 1521-3900
pISSN - 1022-1360
DOI - 10.1002/masy.19971180176
Subject(s) - moiety , polymer , drug delivery , copolymer , ethylene glycol , drug carrier , oligopeptide , materials science , molecule , targeted drug delivery , combinatorial chemistry , peg ratio , drug , small molecule , chemistry , polymer chemistry , nanotechnology , organic chemistry , peptide , biochemistry , finance , economics , psychology , psychiatry
Three types of water‐soluble polymeric drug carrier systems facilitating targeted drug delivery and controlled drug release were synthesized. All systems consist of an inert soluble synthetic polymer, drug and homing device (targeting moiety). In the first “classical” system, both drug and targeting moiety are bound to a nondegradable polymer by means of biodegradable oligopeptide side chains statistically distributed along the polymer chain. The second, “star‐like” system contains a targeting moiety (antibody) in the centre and a hydrophilic polymer, bearing drug molecules, in the shell of the system. The third, “biodegradable” carrier system is based on block copolymers of poly(ethylene glycol) containing biodegradable oligopeptide sequences both in the main polymer chain and in the spacers between main chain and drug molecules. Strategy and details of the synthesis of all three systems are given.