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Negative cilia model for biocompatibility: Sulfonated peo‐grafted polymers and tissues
Author(s) -
Kim Young Ha,
Han Dong Keun,
Park Ki Dong,
Kim Soo Hyun
Publication year - 1997
Publication title -
macromolecular symposia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.257
H-Index - 76
eISSN - 1521-3900
pISSN - 1022-1360
DOI - 10.1002/masy.19971180174
Subject(s) - biocompatibility , ethylene oxide , polyurethane , sulfonate , polymer , in vivo , materials science , polymer chemistry , chemical engineering , chemistry , copolymer , organic chemistry , composite material , microbiology and biotechnology , sodium , engineering , biology
To improve the biocompatibility of polyurethane (PU) and bioprosthetic tissue (BT), they were chemically grafted with a hydrophilic poly(ethylene oxide) (PEO) and further negatively charged sulfonate groups (SO 3 ) to produce PU‐PEO‐SO 3 and BT‐PEO‐SO 3 , respectively. PU‐PEO‐SO 3 was much more blood compatible than untreated PU and PU‐PEO, and the degree of surface cracking and calcification on implanted PUs was decreased in the following order: PU > PU‐PEO > PU‐PEO‐SO 3 . Also, less calcium deposition of BT‐PEO‐SO 3 than that of BT control was observed in in vivo animal tests. Such superior blood compatibility, biostability, and anticalcification of sulfonated PEO‐grafted PUs and tissues might be attributed to synergistic effects of nonadhesive and mobile PEO and negative sulfonate acid groups via a negative cilia model.