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Conjugates of stimuli‐responsive polymers and biomolecules: Random and site‐specific conjugates of temperature‐sensitive polymers and proteins
Author(s) -
Hoffman Allan S.,
Stayton Patrick S.,
Shimoboji Tsuyoshi,
Chen Guohua,
Ding Zhongli,
Chilkoti Ashutosh,
Long Cindi,
Miura Morikazu,
Chen Jingping,
Park Taegwan,
Monji Nobuo,
Cole CarolAnn,
Milton Harris J.,
Nakamae K.
Publication year - 1997
Publication title -
macromolecular symposia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.257
H-Index - 76
eISSN - 1521-3900
pISSN - 1022-1360
DOI - 10.1002/masy.19971180173
Subject(s) - biomolecule , polymer , smart polymer , conjugate , nanotechnology , materials science , chemistry , organic chemistry , mathematical analysis , mathematics
Intelligent polymers exhibit sharp, reversible phase changes in response to small changes in environmental conditions. For example, a small temperature change can cause a sharp precipitation or gelation of a smart polymer solution. Conjugation of these unusual polymers to biomolecules such as enzymes, ligands, lipids, and drugs can lead to many new and exciting applications in medicine and biotechnology. (1–4) This presentation reviews the principles, methodolgies and applications of these “smart” polymer‐biomolecule systems, with special focus on temperature‐sensitive polymer‐protein conjugates.