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Thermosensitive hydrogel coatings: Synthesis and heparin release
Author(s) -
Gutowska Anna,
Kim Sung Wan
Publication year - 1997
Publication title -
macromolecular symposia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.257
H-Index - 76
eISSN - 1521-3900
pISSN - 1022-1360
DOI - 10.1002/masy.19971180172
Subject(s) - copolymer , materials science , self healing hydrogels , polymer chemistry , polymer , polymerization , chemical engineering , composite material , engineering
The synthesis and drug release properties of crosslinked N‐isopropylacrylamide (NiPAAm) copolymer coatings on the surface of a hydrophobic poly(ester‐urethane) tubing were examined. A method was designed to coat hydrophobic polymer surface with a thermosensitive gel layer. Crosslinked NiPAAm copolymer coatings were synthesized using UV‐initiated polymerization. The feasibility of using NiPAAm based gels as heparin releasing thermosensitive coatings was investigated. Heparin, a high molecular weight hydrophilic solute, was loaded into hydrogels using a simple solution sorption technique. The release of heparin from NiPAAm copolymer gel coatings was compared to that of crosslinked NiPAAm copolymers. The gel coatings demonstrated a more gradual and prolonged heparin release as compared to gel disks of the same composition.