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Polysaccharide gels for colon targeting
Author(s) -
Brøndsted Helle,
Hovgaard Lars
Publication year - 1996
Publication title -
macromolecular symposia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.257
H-Index - 76
eISSN - 1521-3900
pISSN - 1022-1360
DOI - 10.1002/masy.19961090108
Subject(s) - polysaccharide , drug delivery , self healing hydrogels , dextran , drug , in vivo , chemistry , targeted drug delivery , drug carrier , in vitro , microbiology and biotechnology , biochemistry , pharmacology , biology , organic chemistry
Polysaccharides appear to have a potential as drug carriers for site‐specific drug delivery to the colon due to the well‐known fermentation of polysaccharides by the anaerobic microflora in the colon. This paper gives a short presentation of the rationale of colon‐specific drug delivery and briefly describes various in vitro and in vivo methods for testing of polysaccharide gels for colonic drug delivery. The application of dextran hydrogels is used as an illustrative example of a polysaccharide based colonic drug delivery system.