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Liposome delivered and polymeric metal complexes as potential sensitizers for the photodynamic therapy of cancer
Author(s) -
Wöhrle Dieter,
Shopova Maria,
Moser Jörg G.,
Kliesch Holger,
Michelsen Ulrike,
Müller Silke,
Weitemeyer Andrea
Publication year - 1996
Publication title -
macromolecular symposia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.257
H-Index - 76
eISSN - 1521-3900
pISSN - 1022-1360
DOI - 10.1002/masy.19961050117
Subject(s) - photodynamic therapy , singlet oxygen , macromolecule , liposome , chemistry , ethylene glycol , covalent bond , metal , photochemistry , polymer , photosensitizer , absorption (acoustics) , ether , combinatorial chemistry , polymer chemistry , materials science , organic chemistry , oxygen , biochemistry , composite material
Different possibilities of macromolecular metal complexes as photosensitizers (PS) for their potential use in the photodynamic therapy of cancer are described. The prepared metal porphyrazin derivatives (metals: Zn(II), Si(IV)(X) 2 ) exhibit long wavelength absorption and high singlet oxygen quantum yields under irradiation. One possibility is the incorporation of the PSs in liposomal vesicles giving hydrophobic conjugates with low densitiy proteins in the serum after injection. Good tumor accumulation and photodynamic activities are observed. Increased tumor uptake is also known for Pcs covalently connected via the ligand to poly(ethylene glycol monomethyl ether). New compounds contain the hydrophilic polymer at axial substituents of Si(X) 2 Pc and Si(X) 2 Nc. Some newly synthesized compounds with only one functional group exhibit the possibility of coupling to macromolecules like e.g. monoclonal antibodies.