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Controlled polymerization of ϵ‐caprolactone ‐from macromolecules to microspheres
Author(s) -
Slomkowski Stanislaw
Publication year - 1996
Publication title -
macromolecular symposia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.257
H-Index - 76
eISSN - 1521-3900
pISSN - 1022-1360
DOI - 10.1002/masy.19961030120
Subject(s) - polymerization , dispersity , polymer chemistry , copolymer , macromolecule , caprolactone , microsphere , polymer , chemistry , materials science , chemical engineering , organic chemistry , biochemistry , engineering
Pseudoanionic polymerization of ϵ‐caprolactone (CL), initiated with dialkylaluminum alkoxides, was used for the tailored synthesis of poly(CL) with M̄ n ≤ 100 000 and M̄ w /M̄ n < 1. 20. Macromolecules with functional groups at one or at both ends were obtained in this way. Controlled polymerization of CL allowed to prepare poly(dodecyl acrylate)‐ g ‐poly(ϵ‐caprolactone) (poly(DAC)‐ g ‐poly(CL)) with well defined poly(CL) grafts. These copolymers were used as the surface active agents for the direct synthesis of poly(CL) microspheres. The number average diameter (D̄ n ) of poly(CL) microspheres varied from 0.628 μm to 0.94 μm and the diameter polydispersity (D̄ v /D̄ n ) varied from 1.038 to 1.26, depending on the composition of poly(DAC)‐ g ‐poly(CL). Human serum albumin (HSA) and human gamma globulins ( γ G) were attached to the poly(CL) microspheres. The maximal surface concentrations of HSA and γ G adsorbed onto the microspheres were equal to 9·10 −4 g/m 2 and 2.0·10 −3 g/m 2 respectively.