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Chirality and dendrimers; the issue of chiral recognition at the nanoscopic level
Author(s) -
Kremers John A.,
Meijer E. W.
Publication year - 1995
Publication title -
macromolecular symposia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.257
H-Index - 76
eISSN - 1521-3900
pISSN - 1022-1360
DOI - 10.1002/masy.19950980139
Subject(s) - dendrimer , chirality (physics) , pentaerythritol , nanoscopic scale , derivative (finance) , nanometre , materials science , chemistry , stereochemistry , nanotechnology , polymer chemistry , organic chemistry , physics , chiral symmetry , composite material , fire retardant , quantum mechanics , nambu–jona lasinio model , financial economics , economics , quark
The synthesis and characterization of two chiral dendrimers, 1 and 2 , in their racemic form is presented. The chirality is based on the construction of four constitutionally different, but chemically resembling, branches to an achiral core. A multi‐substituted pentaerythritol derivative is used as core and Fréchet's aromatic‐ether dendritic wedges of different generation are used as branches. The synthetic approach makes use of the consecutive attachment of the four branches by selective deprotection of the core. Both chiral dendrimers of different size have been synthesized from the same precursor. 1 H‐NMR Spectroscopy indicates an overall chiral shape for 1 , while for both 1 and 2 stratified structures are observed. Several attempts to resolve both dendrimers have not been successful so far, giving rise to a discussion on the degree of chirality in these dendrimers of nanometer dimensions.