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New polymers for biomedical applications: Synthesis and characterization of acrylic systems with pharmacological activity
Author(s) -
Román Julio San,
Gallardo Alberto,
Levenfeld Belén
Publication year - 1994
Publication title -
macromolecular symposia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.257
H-Index - 76
eISSN - 1521-3900
pISSN - 1022-1360
DOI - 10.1002/masy.19940840118
Subject(s) - copolymer , self healing hydrogels , polymer , monomer , polymer chemistry , radical polymerization , biocompatible material , polymerization , materials science , methacrylic acid , swelling , chemistry , organic chemistry , biomedical engineering , medicine , composite material
The synthesis and characterization of new biocompatible “Polymeric Drugs” on the basis of poly (methacrylic esters) and poly (methacrylamides) with side substituents of pharmacological interest, with analgesic, antiinflammatory, antipyretic and antiaggregating activities, is reported. The preparation of these systems was carried out following the universal model suggested by Ringsdorf, and the polymers prepared by the free radical polymerization of the corresponding acrylic monomers were characterized by 1 H‐ and 13 C‐NMR spectroscopies. Biocompatible hydrogels were prepared by free radical copolymerization of these monomers with HEMA. The characteristic copolymerization parameters and the microstructural distribution of comonomeric sequences were determined by NMR spectroscopy. The swelling behaviour of copolymer films was followed gravimetrically. Applications of polymer and copolymer systems are being tested in the fields of pharmacology and vascular surgery.