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Use of poly(ortho esters) in the controlled release of therapeutic agents
Author(s) -
Heller J.,
Roskos K. V.,
Duncan R.
Publication year - 1993
Publication title -
makromolekulare chemie. macromolecular symposia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.257
H-Index - 76
eISSN - 1521-3900
pISSN - 0258-0322
DOI - 10.1002/masy.19930700119
Subject(s) - diketene , transesterification , polymer , chemistry , triol , drug delivery , diol , organic chemistry , combinatorial chemistry , polymer chemistry , materials science , catalysis
Poly(ortho esters) have been under development since 1970 and are the first polymer system that has been specifically designed for drug delivery applications. At this time, three distinctly different families of polymers have been described. One family is prepared by a transesterification reaction between diethoxytetrahydrofuran and a diol, another family is prepared by the reaction of polyols with diketene acetals and the third family is prepared by a transesterification reaction between a triol and an alkyl orthoacetate. The use of these polymers in drug delivery applications is illustrated with 5‐fluorouracil devices used in the treatment of human colorectal cancer xenografted in nude mice and with the delayed release of lysozyme, used as a model protein.