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Molar mass determination of macromolecular compounds by matrix‐assisted laser desorption ionization mass spectrometry
Author(s) -
Karas Michael,
Bahr Ute,
Deppe Andreas,
Stahl Bernd,
Gießmann Ulrich
Publication year - 1992
Publication title -
makromolekulare chemie. macromolecular symposia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.257
H-Index - 76
eISSN - 1521-3900
pISSN - 0258-0322
DOI - 10.1002/masy.19920610131
Subject(s) - mass spectrometry , molar mass , chemistry , matrix assisted laser desorption/ionization , analytical chemistry (journal) , sample preparation in mass spectrometry , desorption , matrix (chemical analysis) , chromatography , mass spectrometry imaging , ionization , electrospray ionization , organic chemistry , polymer , ion , adsorption
Matrix‐assisted laser desorption ionization is a recently developed new ionization technique which enables macromolecular compounds to be investigated by mass spectrometry. The general features of the technique are described, they have so far mainly been worked out for biopolymers such as proteins. Fast and precise molecular weight determination is possible up to 400,000 Dalton. First examples described in this paper indicate that the technique also holds great promise for the investigation of synthetic polymers.