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Surface functionalization and surface recognition: Plasmon optical detection of molecular recognition at self assembled monolayers
Author(s) -
Häußling Lukas,
Knoll Wolfgang,
Ringsdorf Helmut,
Schmitt FranzJosef,
Yang Jianling
Publication year - 1991
Publication title -
makromolekulare chemie. macromolecular symposia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.257
H-Index - 76
eISSN - 1521-3900
pISSN - 0258-0322
DOI - 10.1002/masy.19910460118
Subject(s) - monolayer , surface modification , chemisorption , self assembled monolayer , covalent bond , streptavidin , chemistry , self assembly , aqueous solution , surface plasmon resonance , nanotechnology , chemical engineering , photochemistry , biotin , materials science , organic chemistry , adsorption , nanoparticle , biochemistry , engineering
The synthesis of biotin‐ functionalized organic mercaptans and their chemisorption on gold surfaces is described. Biotin bound covalently to self assembled monolayers is recognized by streptavidin from aqueous buffer solutions. Spacer length and packing density of the biotin labels on the organic surface determine the docking kinetics. With a flexible and hydrophilic spacer very fast ‐diffusion controlled‐docking is observed. As an alternative method of self assembly the spreading of organic mercaptans on water surfaces is established. Pressure‐area diagrams of different functionalized mercaptans and disulfides are shown and their monolayer properties are discussed.