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The two‐dimensional NMR spectroscopy of macromolecules
Author(s) -
Bovey Frank A.,
Mirau Peter A.
Publication year - 1990
Publication title -
makromolekulare chemie. macromolecular symposia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.257
H-Index - 76
eISSN - 1521-3900
pISSN - 0258-0322
DOI - 10.1002/masy.19900340102
Subject(s) - two dimensional nuclear magnetic resonance spectroscopy , spectroscopy , nuclear magnetic resonance spectroscopy , nuclear overhauser effect , polymer , chemistry , macromolecule , nmr spectra database , spectral line , chemical shift , j coupling , transverse relaxation optimized spectroscopy , resolution (logic) , carbon 13 nmr satellite , fluorine 19 nmr , interpretation (philosophy) , chemical physics , crystallography , stereochemistry , physics , organic chemistry , biochemistry , quantum mechanics , astronomy , artificial intelligence , computer science , programming language
Two‐dimensional (2D) NMR is a versatile technique which exists in many versions. Two broad classes of 2D techniques are (1) correlated spectroscopy and (2) J‐resolved spectroscopy. The first of these may be divided into two further subdivisions: COSY, which permits correlations of resonances via J‐coupling, and NOESY, which allows direct measurement of intenuclear (usually interproton) distances by the nuclear Overhauser effect. COSY greatly facilitates the interpretation of complex spectra and spectral interpretation in terms of stereochemical sequences is placed on a firmer foundation. NOESY provides direct information concerning the local conformations of polymers in solution. By use of J‐resolved 2D NMR, we can separate J‐couplings and chemical shifts on different axes and thus achieve a degree of resolution of both these parameters far beyond what is attainable in the 1D spectrum. Finally, we may combine correlated and J‐resolved spectroscopy and achieve the benefits of both in 3D NMR , in which the 2D cross peaks exhibit J‐coupling fine structure. These techniques are illustrated for a variety of polymers including poly(methyl methacrylate), poly(vinyl fluoride), poly‐y‐benzyl L‐glutamate, and poly(propylene oxide) .