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Surface modification of polyurethane for enhanced blood compatibility
Author(s) -
Kim Young Ha,
Han Dong Keun,
Jeong Seo Young,
Ahn KwangDuk
Publication year - 1990
Publication title -
makromolekulare chemie. macromolecular symposia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.257
H-Index - 76
eISSN - 1521-3900
pISSN - 0258-0322
DOI - 10.1002/masy.19900330127
Subject(s) - polyurethane , ethylene oxide , surface modification , ex vivo , sulfonate , heparin , platelet activation , polymer chemistry , platelet adhesion , platelet , in vivo , adhesion , chemistry , materials science , in vitro , copolymer , polymer , organic chemistry , biochemistry , sodium , medicine , immunology , microbiology and biotechnology , biology
Surfaces of commercial polyurethanes (PUs) were modified by poly(ethylene oxide) (PEO) grafting and/or heparin immobilization or sulfonation to investigate the effect to antithrombogenicity. The hydrophilicity of the modified PUs surface was significantly increased. All the PEO‐grafted PU surfaces displayed very little platelet adhesion and activation. The coupled heparin or sulfonate at the end of PEO exhibited anticoagulant activity to extend APTT. Lowering in vitro platelet adhesion of modified PUs led to a prolongation in the ex vivo occlusion time. In particular, the sulfonated PU‐PEO surface showed the most enhanced blood compatibility due to the synergistic effects of PEO and SO 3 groups.