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Biologically active polymer ‐ targeting polymeric antitumor agents‐
Author(s) -
Han Man Jung,
Choi Keun Bae,
Kim Ki Ho,
Hahn Bo Sup,
Lee Won Young
Publication year - 1990
Publication title -
makromolekulare chemie. macromolecular symposia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.257
H-Index - 76
eISSN - 1521-3900
pISSN - 0258-0322
DOI - 10.1002/masy.19900330125
Subject(s) - in vivo , maleic anhydride , moiety , conjugate , polymer , in vitro , chemistry , combinatorial chemistry , biochemistry , organic chemistry , biology , copolymer , mathematical analysis , microbiology and biotechnology , mathematics
To synthesize targeting polymeric antitumor agents, poly[(2‐acetoxy‐3,4‐dihydro‐2H‐pyran)‐ alt ‐(maleic anhydride)] as polymer backbone, chlorophyll derivatives(CpD) extracted from silkworm excreta as targeting moiety and 5‐fluorouracil and 6‐mercaptopurine as pharmacons were selected. The polymer exhibited an antitumor activity comparable to that of cyclophosphamide in vivo. CpD as well as CpD‐polymer conjugate were localized on tumor cells in vitro and delivered to tumor tissues in vivo specifically. The targeting polymeric antitumor agents were synthesized by coupling pharmacons and CpD on the polymer chain with the aid of reactions between functionalities of the reactants and anhydride groups on the polymer backbone. Various tests of their biological activities in vivo are in progress.