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Noncovalent complexes of water‐soluble polymers and organoplatinum compounds as potential time‐release antitumor agents
Author(s) -
Howell B. A.,
Walles E. W.,
Rashidianfar R.
Publication year - 1988
Publication title -
makromolekulare chemie. macromolecular symposia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.257
H-Index - 76
eISSN - 1521-3900
pISSN - 0258-0322
DOI - 10.1002/masy.19880190126
Subject(s) - platinum , chemistry , polymer , polymer chemistry , combinatorial chemistry , water soluble , organic chemistry , catalysis
The complexation of appropriate organoplatinum compounds by water‐soluble polymers has the potential to provide a time‐release formulation which might afford a substantial reduction in the severity of side effects associated with use of organoplatinum antitumor agents. Both poly‐(N‐vinylpyrrolidone)(PVP) and poly(N‐vinyl‐5‐methyl‐2‐oxazolidone)(PVOM) form stable, biologically active, molecular complexes with organoplatinum compounds containing polar aromatic ligands. Platinum compounds suitable for complexation by these polymers include cis‐dichloro(4‐substituted o‐phenylenediamine)platinum(II), 4‐substitutedcatecholato(1,2‐diaminocyclohexane)platinum(II), and 4‐substitutedphthallato(1,2‐diaminocyclohexane)‐platinum(II) compounds.