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Evaluation op some cellulosic derivatives as carriers for different drugs
Author(s) -
Dumitriu Severian,
Popa Marcel,
Beldie Cameluta
Publication year - 1988
Publication title -
makromolekulare chemie. macromolecular symposia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.257
H-Index - 76
eISSN - 1521-3900
pISSN - 0258-0322
DOI - 10.1002/masy.19880190125
Subject(s) - cellulose , chemistry , cellulosic ethanol , methyl cellulose , organic chemistry
Three cellulosic derivatives, namely xanthan, (chlorocarbonyl methyl) cellulose and N‐(4‐carboxyphenyl)carbamoyl methyl cellulose were used as support in coupling different drugs. Pilocarpine and neomycine were ionically coupled on xanthan; nalidixic acid, metronidazole and cephalosporine C were covalently coupled on (chlorocarbonyl methyl) cellulose, xanthan and N‐(4‐carboxyphenyl)carbamoyl methyl cellulose, in the latter case dicyclohexylcarbodiimide being used as activator. The influence of some factors on coupling efficiency was followed: drug/support ratio, volume of the solvent, reaction duration, activator/support ratio. The in vitro and in vivo tests proved the biological activity of the newly obtained macromolecular drugs.