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Ultrasonically controlled polymeric drug delivery
Author(s) -
Kost J.,
Leong K.,
Langer R.
Publication year - 1988
Publication title -
makromolekulare chemie. macromolecular symposia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.257
H-Index - 76
eISSN - 1521-3900
pISSN - 0258-0322
DOI - 10.1002/masy.19880190122
Subject(s) - drug delivery , smart polymer , polymer , in vivo , drug , biomedical engineering , permeation , ultrasound , materials science , nanotechnology , chemistry , pharmacology , composite material , medicine , biology , microbiology and biotechnology , biochemistry , radiology , membrane
The area of polymeric controlled drug delivery systems has been a field of increasing interest. However, relatively little attention has been given to developing systems in which the rate of delivery can be manipulated externally. We now report that release rates of biologically active substances from a polymeric matrix can be repeatedly modulated from a position external to the environment of use by ultrasonic energy. The ultrasound affects the degradation rate of bioerodible polymers as well as permeation through non‐erodible polymers. The system has been shown to be responsive in vivo. Skin histopathology of the ultrasound treated area didn't reveal any differences between the treated skin and the untreated controls.