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Surfacial modification of polymer powders as drug carriers
Author(s) -
Matsubara Yoshio,
Yagi Tooru,
Yamashita Natsuki,
Maeshima Toshihisa
Publication year - 1988
Publication title -
makromolekulare chemie. macromolecular symposia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.257
H-Index - 76
eISSN - 1521-3900
pISSN - 0258-0322
DOI - 10.1002/masy.19880190117
Subject(s) - copolymer , benzene , methacrylate , hydrolysis , polymer chemistry , polymer , vinyl chloride , drug delivery , materials science , drug carrier , chemistry , organic chemistry
Preparation of warfarin methacrylate(WaMA) was carried out by esterification of warfarin as thromboembolism drug with methacryloyl chloride. Radical copolymerization of WaMA with 1‐vinyl‐2‐pyrrolidone(VPr) was carried out in 1,4‐dioxane at 60°C using 2,2′‐azoisobutyronitrile as initiator. The surfacial modification of the copolymer powders was achieved using the freeze‐drying by dissolving the copolymer in benzene and micellation by benzene‐in‐water and water‐in‐benzene systems. The hydrolysis of the copolymer including the drug was investigated under mild condition from a view point of released rate of the drug.