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Neutron scattering studies of the structure and assembly of spherical viruses
Author(s) -
Timmins Peter A.
Publication year - 1988
Publication title -
makromolekulare chemie. macromolecular symposia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.257
H-Index - 76
eISSN - 1521-3900
pISSN - 0258-0322
DOI - 10.1002/masy.19880150124
Subject(s) - scattering , neutron scattering , virus , neutron , physics , small angle neutron scattering , spherical shell , resolution (logic) , virology , optics , biology , materials science , nuclear physics , shell (structure) , computer science , artificial intelligence , composite material
Studies of the structure of spherical viruses, using both classical solution scattering techniques, and in favourable cases, the technique of low‐resolution neutron crystallography, are described. Solution scattering studies, which began with the determination of the radial distribution of the various viral components, have evolved to the stage where it is now possible to follow the in vitro reassembly of virus particles. The limitations of spherical averaging present in solution scattering can in certain cases be overcome by the application of the contrast variation method to single crystals of a virus. Application of this technique to the structure of tomato bushy stunt virus (TBSV) is described.