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On the regulation of the interaction of synthetic polymers with blood
Author(s) -
Valuev L. I.,
Chupov V. V.,
Platé N. A.
Publication year - 1986
Publication title -
makromolekulare chemie. macromolecular symposia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.257
H-Index - 76
eISSN - 1521-3900
pISSN - 0258-0322
DOI - 10.1002/masy.19860040127
Subject(s) - lysis , heparin , trypsin , fibrinogen , chemistry , protease , polymer , ternary complex , ternary operation , blood proteins , chromatography , substrate (aquarium) , serum albumin , combinatorial chemistry , biochemistry , organic chemistry , enzyme , biology , computer science , ecology , programming language
Abstract The interaction of polymeric hydrogels containing immobilized trypsin and heparin with serum, blood and model solutions of serum proteins has been studied. It has been shown that these binary systems have high haemocompatibility due to specific fibrinogen binding by immobilized heparin and the subsequent lysis of bound substrate by immobilized protease. The lysis is accelerated in the presence of serum albumin and such materials may be regarded as biologically active ternary polymers.