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Collagen analysis with mass spectrometry
Author(s) -
Huizen Nick A.,
Ijzermans Jan N.M.,
Burgers Peter C.,
Luider Theo M.
Publication year - 2019
Publication title -
mass spectrometry reviews
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.035
H-Index - 126
eISSN - 1098-2787
pISSN - 0277-7037
DOI - 10.1002/mas.21600
Subject(s) - chemistry , mass spectrometry , supramolecular chemistry , chromatography , molecule , organic chemistry
Mass spectrometry‐based techniques can be applied to investigate collagen with respect to identification, quantification, supramolecular organization, and various post‐translational modifications. The continuous interest in collagen research has led to a shift from techniques to analyze the physical characteristics of collagen to methods to study collagen abundance and modifications. In this review, we illustrate the potential of mass spectrometry for in‐depth analyses of collagen.