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The challenges of peptidomics in complementing proteomics in a clinical context
Author(s) -
Maes Evelyne,
Oeyen Eline,
Boonen Kurt,
Schildermans Karin,
Mertens Inge,
Pauwels Patrick,
Valkenborg Dirk,
Baggerman Geert
Publication year - 2018
Publication title -
mass spectrometry reviews
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.035
H-Index - 126
eISSN - 1098-2787
pISSN - 0277-7037
DOI - 10.1002/mas.21581
Subject(s) - proteomics , context (archaeology) , chemistry , computational biology , data science , computer science , biochemistry , biology , paleontology , gene
Naturally occurring peptides, including growth factors, hormones, and neurotransmitters, represent an important class of biomolecules and have crucial roles in human physiology. The study of these peptides in clinical samples is therefore as relevant as ever. Compared to more routine proteomics applications in clinical research, peptidomics research questions are more challenging and have special requirements with regard to sample handling, experimental design, and bioinformatics. In this review, we describe the issues that confront peptidomics in a clinical context. After these hurdles are (partially) overcome, peptidomics will be ready for a successful translation into medical practice.