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Imaging mass spectrometry: Instrumentation, applications, and combination with other visualization techniques
Author(s) -
BodzonKulakowska Anna,
Suder Piotr
Publication year - 2015
Publication title -
mass spectrometry reviews
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.035
H-Index - 126
eISSN - 1098-2787
pISSN - 0277-7037
DOI - 10.1002/mas.21468
Subject(s) - chemistry , mass spectrometry imaging , mass spectrometry , instrumentation (computer programming) , visualization , nanotechnology , biochemical engineering , field (mathematics) , chromatography , computer science , artificial intelligence , materials science , mathematics , pure mathematics , engineering , operating system
Imaging Mass Spectrometry (IMS) is strengthening its position as a valuable analytical tool. It has unique ability to identify structures and to unravel molecular changes that occur in the precisely defined part of the sample. These unique features open new possibilities in the field of various aspects of biological research. In this review we briefly discuss the main imaging mass spectrometry techniques, as well as the nature of biological samples and molecules, which might be analyzed by such methodology. Moreover, a novel approach, where different analytical techniques might be combined with the results of IMS study, is emphasized and discussed. With such a fast development of IMS and related methods, we can foresee the promising future of this technique. © 2015 Wiley Periodicals, Inc. Mass Spec Rev 35: 147–169, 2016.