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Differential mobility spectrometry/mass spectrometry history, theory, design optimization, simulations, and applications
Author(s) -
Schneider Bradley B.,
Nazarov Erkinjon G.,
Londry Frank,
Vouros Paul,
Covey Thomas R.
Publication year - 2015
Publication title -
mass spectrometry reviews
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.035
H-Index - 126
eISSN - 1098-2787
pISSN - 0277-7037
DOI - 10.1002/mas.21453
Subject(s) - chemistry , mass spectrometry , ion mobility spectrometry , ion mobility spectrometry–mass spectrometry , coupling (piping) , flexibility (engineering) , differential (mechanical device) , chromatography , tandem mass spectrometry , selected reaction monitoring , aerospace engineering , mechanical engineering , engineering , statistics , mathematics
This review of differential mobility spectrometry focuses primarily on mass spectrometry coupling, starting with the history of the development of this technique in the Soviet Union. Fundamental principles of the separation process are covered, in addition to efforts related to design optimization and advancements in computer simulations. The flexibility of differential mobility spectrometry design features is explored in detail, particularly with regards to separation capability, speed, and ion transmission. 2015 Wiley Periodicals, Inc. Mass Spec Rev 35:687–737, 2016