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Fourier transform ion cyclotron resonance (FT ICR) mass spectrometry: Theory and simulations
Author(s) -
Nikolaev Eugene N.,
Kostyukevich Yury I.,
Vladimirov Gleb N.
Publication year - 2014
Publication title -
mass spectrometry reviews
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.035
H-Index - 126
eISSN - 1098-2787
pISSN - 0277-7037
DOI - 10.1002/mas.21422
Subject(s) - fourier transform ion cyclotron resonance , chemistry , mass spectrometry , ion cyclotron resonance , selected ion monitoring , ion trap , hybrid mass spectrometer , ion , quadrupole ion trap , cyclotron , orbitrap , analytical chemistry (journal) , ion mobility spectrometry–mass spectrometry , top down proteomics , selected reaction monitoring , chromatography , gas chromatography–mass spectrometry , tandem mass spectrometry , organic chemistry
Fourier transform ion cyclotron resonance (FT ICR) mass spectrometer offers highest resolving power and mass accuracy among all types of mass spectrometers. Its unique analytical characteristics made FT ICR important tool for proteomics, metabolomics, petroleomics, and investigation of complex mixtures. Signal acquisition in FT ICR MS takes long time (up to minutes). During this time ion–ion interaction considerably affects ion motion and result in decreasing of the resolving power. Understanding of those effects required complicated theory and supercomputer simulations but culminated in the invention of the ion trap with dynamic harmonization which demonstrated the highest resolving power ever achieved. In this review we summarize latest achievements in theory and simulation of FT ICR mass spectrometers. © 2014 Wiley Periodicals, Inc. Mass Spec Rev 35:219–258, 2016.