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The role of mass spectrometry in the analysis of vitamin D compounds
Author(s) -
Gathungu Rose M.,
Flarakos Caroline C.,
Satyanarayana Reddy G.,
Vouros Paul
Publication year - 2012
Publication title -
mass spectrometry reviews
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.035
H-Index - 126
eISSN - 1098-2787
pISSN - 0277-7037
DOI - 10.1002/mas.21353
Subject(s) - chemistry , mass spectrometry , chromatography , vitamin , biochemistry
Abstract This review highlights the superseding role of mass spectrometry in the structural characterization and quantitation of vitamin D compounds in comparison to other analytical methods (e.g., UV, bioassays) that lack the sensitivity and specificity of mass spectrometry. After a short introduction to the biochemistry of vitamin D compounds, an overview of the current techniques to characterize and quantitate vitamin D compounds is given with emphasis on the contribution of mass spectrometry. © 2012 Wiley Periodicals, Inc., Mass Spec Rev 32:72–86, 2013