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Determination of drugs and drug‐like compounds in different samples with direct analysis in real time mass spectrometry
Author(s) -
Chernetsova Elena S.,
Morlock Gertrud E.
Publication year - 2011
Publication title -
mass spectrometry reviews
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.035
H-Index - 126
eISSN - 1098-2787
pISSN - 0277-7037
DOI - 10.1002/mas.20304
Subject(s) - dart ion source , chemistry , mass spectrometry , chromatography , dart , ionization , mass spectrum , analytical chemistry (journal) , sample preparation , ambient ionization , chemical ionization , electron ionization , organic chemistry , ion , computer science , programming language
Direct analysis in real time (DART), a relatively new ionization source for mass spectrometry, ionizes small‐molecule components from different kinds of samples without any sample preparation and chromatographic separation. The current paper reviews the published data available on the determination of drugs and drug‐like compounds in different matrices with DART‐MS, including identification and quantitation issues. Parameters that affect ionization efficiency and mass spectra composition are also discussed. © 2011 Wiley Periodicals, Inc., Mass Spec Rev 30:875–883, 2011