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The role of mass spectrometry‐based metabolomics in medical countermeasures against radiation
Author(s) -
Patterson Andrew D.,
Lanz Christian,
Gonzalez Frank J.,
Idle Jeffrey R.
Publication year - 2009
Publication title -
mass spectrometry reviews
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.035
H-Index - 126
eISSN - 1098-2787
pISSN - 0277-7037
DOI - 10.1002/mas.20272
Subject(s) - metabolomics , biodosimetry , chemistry , mass spectrometry , ionizing radiation , computational biology , chromatography , irradiation , biology , physics , nuclear physics
Radiation metabolomics can be defined as the global profiling of biological fluids to uncover latent, endogenous small molecules whose concentrations change in a dose–response manner following exposure to ionizing radiation. In response to the potential threat of nuclear or radiological terrorism, the Center for High‐Throughput Minimally Invasive Radiation Biodosimetry was established to develop field‐deployable biodosimeters based, in part, on rapid analysis by mass spectrometry of readily and easily obtainable biofluids. In this review, we briefly summarize radiation biology and key events related to actual and potential nuclear disasters, discuss the important contributions the field of mass spectrometry has made to the field of radiation metabolomics, and summarize current discovery efforts to use mass spectrometry‐based metabolomics to identify dose‐responsive urinary constituents, and ultimately to build and deploy a noninvasive high‐throughput biodosimeter. © 2009 Wiley Periodicals, Inc. Mass Spec Rev 29:503‐521, 2010