Premium
Mass spectrometry‐based proteomics in reproductive medicine
Author(s) -
Kolialexi Aggeliki,
Mavrou Ariadni,
Spyrou George,
Tsangaris George Th.
Publication year - 2008
Publication title -
mass spectrometry reviews
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.035
H-Index - 126
eISSN - 1098-2787
pISSN - 0277-7037
DOI - 10.1002/mas.20181
Subject(s) - proteomics , proteome , follicular fluid , chemistry , pregnancy , amniotic fluid , computational biology , physiology , medicine , biology , fetus , biochemistry , embryo , genetics , oocyte , gene , microbiology and biotechnology
The emergence of powerful mass spectrometry‐based proteomic techniques has added a new dimension to the field of biomedical research. Application of these high throughput methodologies in pregnancy‐related pathology has contributed to the comprehension of the underlying pathophysiologies and the successful identification of relevant protein biomarkers that can potentially change early diagnosis and treatment of several medical conditions related to human pregnancy. Most of the existing research on human reproduction and gestation has focused on follicular fluid, cervical/vaginal fluid, and amniotic fluid. Although proteome technologies in reproductive medicine research are not as yet widely applied, characterization of the proteome of reproductive fluids can be expected to significantly improve maternal healthcare. This article aims to summarize the applications of mass spectrometry based technology on the most important and specific biological fluids related to reproduction and gestation. © 2008 Wiley Periodicals, Inc., Mass Spec Rev 27: 624–634, 2008