Premium
Advances in proteomics data analysis and display using an accurate mass and time tag approach
Author(s) -
Zimmer Jennifer S.D.,
Monroe Matthew E.,
Qian WeiJun,
Smith Richard D.
Publication year - 2006
Publication title -
mass spectrometry reviews
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.035
H-Index - 126
eISSN - 1098-2787
pISSN - 0277-7037
DOI - 10.1002/mas.20071
Subject(s) - proteomics , chemistry , mass spectrometry , computational biology , chromatography , biochemistry , gene , biology
Proteomics has recently demonstrated utility for increasing the understanding of cellular processes on the molecular level as a component of systems biology approaches and for identifying potential biomarkers of various disease states. The large amount of data generated by utilizing high efficiency (e.g., chromatographic) separations coupled with high mass accuracy mass spectrometry for high‐throughput proteomics analyses presents challenges related to data processing, analysis, and display. This review focuses on recent advances in nanoLC‐FTICR‐MS‐based proteomics approaches and the accompanying data processing tools that have been developed to display and interpret the large volumes of data being produced. © 2006 Wiley Periodicals, Inc., Mass Spec Rev 25:450–482, 2006