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Mass spectrometry in bioinorganic analytical chemistry
Author(s) -
Łobiński Ryszard,
Schaumlöffel Dirk,
Szpunar Joanna
Publication year - 2005
Publication title -
mass spectrometry reviews
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.035
H-Index - 126
eISSN - 1098-2787
pISSN - 0277-7037
DOI - 10.1002/mas.20069
Subject(s) - chemistry , biomolecule , mass spectrometry , capillary electrophoresis , analyte , inductively coupled plasma mass spectrometry , chromatography , bioinorganic chemistry , electrospray , analytical chemistry (journal) , environmental chemistry , organic chemistry , biochemistry
Abstract A considerable momentum has recently been gained by in vitro and in vivo studies of interactions of trace elements in biomolecules due to advances in inductively coupled plasma mass spectrometry (ICP MS) used as a detector in chromatography and capillary and planar electrophoresis. The multi‐isotopic (including non‐metals such as S, P, or Se) detection capability, high sensitivity, tolerance to matrix, and large linearity range regardless of the chemical environment of an analyte make ICP MS a valuable complementary technique to electrospray MS and MALDI MS. This review covers different facets of the recent progress in metal speciation in biochemistry, including probing in vitro interactions between metals and biomolecules, detection, determination, and structural characterization of heteroatom‐containing molecules in biological tissues, and protein monitoring and quantification via a heteroelement (S, Se, or P) signal. The application areas include environmental chemistry, plant and animal biochemistry, nutrition, and medicine. © 2005 Wiley Periodicals, Inc. Mass Spec Rev 25:255–289, 2006