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Mass spectrometry in aging research
Author(s) -
Schöneich Christian
Publication year - 2004
Publication title -
mass spectrometry reviews
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.035
H-Index - 126
eISSN - 1098-2787
pISSN - 0277-7037
DOI - 10.1002/mas.20035
Subject(s) - chemistry , mass spectrometry , proteomics , current (fluid) , computational biology , biochemical engineering , chromatography , biochemistry , thermodynamics , physics , biology , engineering , gene
This review covers the application of mass spectrometric techniques to aging research. Modern proteomic strategies will be discussed as well as the targeted analysis of specific proteins for the correlation of post‐translational modifications with protein function. Selected examples will show both the power and also current limitations of the respective techniques. Experimental results and strategies are discussed in view of current theories of the aging process. © 2004 Wiley Periodicals, Inc., Mass Spec Rev 24:701–718, 2005