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Dimethyl ether chemical ionization mass spectrometry
Author(s) -
Burrows Elizabeth P.
Publication year - 1995
Publication title -
mass spectrometry reviews
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.035
H-Index - 126
eISSN - 1098-2787
pISSN - 0277-7037
DOI - 10.1002/mas.1280140204
Subject(s) - chemistry , mass spectrometry , chemical ionization , ether , direct electron ionization liquid chromatography–mass spectrometry interface , chromatography , atmospheric pressure chemical ionization , dimethyl ether , ionization , analytical chemistry (journal) , organic chemistry , ion , methanol
The uses of dimethyl ether (DME) as an unusual positive ion reagent for chemical ionization mass spectrometry (CIMS) are reviewed. The fragment–molecule adducts formed by ion–molecule reactions of organic substrates with the ionized gas are highly characteristic for the substrates and frequently can be used to differentiate among isomers. The fragmentation mechanisms of the adducts have been studied by collision‐induced dissociation and with deuterium labeling, and, in some cases, are well‐understood. DME CIMS has been applied to a wide variety of classes of organic compounds, including substituted aromatics, amino alcohols, lactones, lactams, polyethylene glycols, benzodiazepines, azepines, trichothecenes, and certain alkaloids, nucleoside antibiotics, and polynuclear aromatic hydrocarbons. © 1996 John Wiley & Sons, Inc.