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Stimuli‐Responsive Block Copolymer Micelles Based on Mussel‐Inspired Metal‐Coordinated Supramolecular Networks
Author(s) -
Ganguly Ritabrata,
Saha Pabitra,
Banerjee Sovan Lal,
Pich Andrij,
Singha Nikhil K.
Publication year - 2021
Publication title -
macromolecular rapid communications
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.348
H-Index - 154
eISSN - 1521-3927
pISSN - 1022-1336
DOI - 10.1002/marc.202100312
Subject(s) - micelle , catechol , copolymer , amphiphile , moiety , supramolecular chemistry , polymerization , nanocarriers , raft , aqueous solution , metal ions in aqueous solution , reversible addition−fragmentation chain transfer polymerization , polymer chemistry , ferric , materials science , chemistry , metal , combinatorial chemistry , organic chemistry , polymer , drug delivery , radical polymerization , molecule
Amphiphilic diblock copolymers containing dopamine and zwitterions are synthesized via the RAFT polymerization method, which undergo temperature‐mediated micellization in aqueous media. The presence of catechol moiety in dopamine is exploited to form pH‐responsive cross‐links with ferric ions (Fe 3+ ) at different pH value. Herein, a comprehensive study of the effect of pH as well as temperature on the size and solution behavior of these cross‐linked micelles is presented. These micelles cross‐linked via metal–catechol coordination bonds can have several important biomedical applications such as degradable scaffolds for payload delivery.