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Accelerated Redox Reaction of Hydrogen Peroxide by Employing Locally Concentrated State of Copper Catalysts on Polymer Chain
Author(s) -
Osawa Shigehito,
Kitanishi Kenichi,
Kiuchi Maho,
Shimonaka Motoyuki,
Otsuka Hidenori
Publication year - 2021
Publication title -
macromolecular rapid communications
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.348
H-Index - 154
eISSN - 1521-3927
pISSN - 1022-1336
DOI - 10.1002/marc.202100274
Subject(s) - hydrogen peroxide , catalysis , redox , chemistry , copper , polymer , half reaction , peroxide , decomposition , combinatorial chemistry , photochemistry , polymer chemistry , inorganic chemistry , organic chemistry
Copper complexes act as catalysts for redox reactions to generate reactive oxygen species that destroy biomolecules and, therefore, are utilized to design drugs including antitumor and antibacterial medicines. Especially, catalytic reaction for hydrogen peroxide decomposition is important because it includes the process for generating highly toxic hydroxyl radical, i.e., Fenton‐like reaction. Considering that multicoppers/hydrogen peroxide species are the important intermediates for the redox reaction, herein a polymer having copper complexes in the side chains is designed to facilitate the formation of the intermediates by building locally concentrated state of the copper complexes. The polymer increases their catalytic activities for hydrogen peroxide decomposition and promotes reactive oxygen species’ generation, eventually leading to higher antibacterial activity. This reveals the virtue of building a locally concentrated state of catalysts on polymers toward drug design with low amounts of transition metals.