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4D Printing of Shape Memory Vascular Stent Based on β CD‐ g ‐Polycaprolactone
Author(s) -
Zhou Yanyi,
Zhou, Dong,
Cao Pengrui,
Zhang Xinrui,
Wang Qihua,
Wang Tingmei,
Li Zhaolong,
He Wenyang,
Ju Junping,
Zhang Yaoming
Publication year - 2021
Publication title -
macromolecular rapid communications
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.348
H-Index - 154
eISSN - 1521-3927
pISSN - 1022-1336
DOI - 10.1002/marc.202100176
Subject(s) - polycaprolactone , biocompatibility , materials science , stent , ultimate tensile strength , composite number , polymerization , drug delivery , biomedical engineering , composite material , polymer , nanotechnology , surgery , medicine , metallurgy
The 4D‐printing technology is applied to fabricate a shape memory peripheral stent with good biocompatibility, which sustains long‐term drug release. The star polymer s‐PCL is prepared by ring opening polymerization of ε ‐caprolactone with the ‐OH of β ‐cyclodextrin ( β CD) as initiator, and then the s‐PCL is modified with acrylate endgroup which allows the polymerization under UV light to form the crosslinking network c‐PCL. Attributed to the feature of the high crosslinked structure and chemical nature of polycaprolactone (PCL) and β CD, the composite exhibits appropriate tensile strength and sufficient elasticity and bursting pressure, and it is comparable with great saphenous vein in human body. The radial support of the 4D‐printed stent is 0.56 ± 0.11 N and is equivalent to that of commercial stent. The cell adhesion and proliferation results show a good biocompatibility of the stent with human umbilical vein endothelial cells. Due to the presence of β CD, the wettability and biocompatibility of the materials are improved, and the sustained paclitaxel release based on the host–guest complexion shows the potential of the drug‐loaded stent for long‐term release. This study provides a new strategy to solve the urgent need of small‐diameter scaffolds to treat critical limb ischemia.