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Surface Modification of Parylene C Film via Buchwald–Hartwig Amination for Organic Solvent‐Compatible and Flexible Microfluidic Channel Bonding
Author(s) -
Satheeshkumar Chinnadurai,
Jung BumJoon,
Jang Hansol,
Lee Wonhee,
Seo Myungeun
Publication year - 2021
Publication title -
macromolecular rapid communications
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.348
H-Index - 154
eISSN - 1521-3927
pISSN - 1022-1336
DOI - 10.1002/marc.202000520
Subject(s) - amination , surface modification , amine gas treating , materials science , covalent bond , polymer , polymer chemistry , microfluidics , isocyanate , chemical engineering , dendrimer , molecule , functional group , solvent , combinatorial chemistry , nanotechnology , organic chemistry , chemistry , polyurethane , catalysis , composite material , engineering
Surface modification offers an efficient and economical route to installing functional groups on a polymer surface. This work demonstrates that primary amine groups can be introduced onto a polymer surface via Buchwald–Hartwig amination, and the functionalized substrates can be chemically bonded to produce functional microfluidic devices. By activating the CCl bond in commercially used poly(chloro‐ p ‐xylylene) (parylene C) by Pd catalyst and substituting Cl with the amine source, the amine groups are successfully installed in a facile and recyclable manner. The substrates can be covalently bonded with each other via amine‐isocyanate chemistry, providing much higher bonding strength compared to previous methods based on noncovalent adhesive coatings. As a result, transparent and flexible microfluidic channels can be fabricated that are compatible with organic solvents and high pressure. Retention of amine group reactivity in the channel suggests the potential of this methodology for the surface immobilization of functional molecules for microfluidic reactors and biosensors.

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