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Transparent Conductive Supramolecular Hydrogels with Stimuli‐Responsive Properties for On‐Demand Dissolvable Diabetic Foot Wound Dressings
Author(s) -
Zhao Yue,
Li Zuhao,
Li Qiuju,
Yang Longfei,
Liu Hou,
Yan Ruyue,
Xiao Lizhi,
Liu He,
Wang Jingcheng,
Yang Bai,
Lin Quan
Publication year - 2020
Publication title -
macromolecular rapid communications
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.348
H-Index - 154
eISSN - 1521-3927
pISSN - 1022-1336
DOI - 10.1002/marc.202000441
Subject(s) - self healing hydrogels , wound healing , wound dressing , on demand , wound care , diabetic foot , supramolecular polymers , materials science , debridement (dental) , supramolecular chemistry , nanotechnology , biomedical engineering , medicine , surgery , chemistry , polymer chemistry , computer science , composite material , diabetes mellitus , crystal structure , endocrinology , multimedia , crystallography
Diabetic foot ulcers (DFU) remain a very considerable health care burden, and their treatment is difficult. Hydrogel‐based wound dressings are appealing to provide an optimal environment for wound repair. However, the currently available hydrogel dressings still need surgical or mechanical debridement from the wound, causing reinjury of the newly formed tissues, wound infection, delayed healing time, and personal suffering. Additionally, to meet people's increasing demand, hydrogel wound dressings with improved performance and multifunctionality are urgently required. Here, a new multifunctional supramolecular hydrogel for on‐demand dissolvable diabetic foot wound dressings is designed and constructed. Based on multihydrogen bonds between hydrophilic polymers, the resultant supramolecular hydrogels present controlled and excellent properties, such as good transparency, antibacterial ability, conductive, and self‐healing properties. Thus, the supramolecular hydrogels improve the new tissue formation and provide a significant therapeutic effect on DFU by inducing angiogenesis, enhancing collagen deposition, preventing bacterial infection, and controlling wound infection. Remarkably, the resultant hydrogels also exhibit stimuli‐responsive ability, which renders its capability to be dissolved on‐demand, allowing for a facile DFU dressing removal. This multifunctional supramolecular hydrogel may provide a novel concept in the design of on‐demand dissolvable wound dressings.