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Templated Polymerization of Nucleobase Complexes via Molecular Recognition
Author(s) -
Wang Mu,
Chu Fuke,
Xiao Jingjing,
Choi Bonnie,
Wei Xiaohu,
Feng Anchao
Publication year - 2020
Publication title -
macromolecular rapid communications
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.348
H-Index - 154
eISSN - 1521-3927
pISSN - 1022-1336
DOI - 10.1002/marc.202000352
Subject(s) - nucleobase , thymine , polymerization , chemistry , supramolecular chemistry , chain transfer , hydrogen bond , molecular recognition , polymer chemistry , cytosine , template , base pair , stereochemistry , dna , molecule , materials science , radical polymerization , polymer , organic chemistry , nanotechnology , biochemistry
Macromolecules have a strong tendency to interact with each other in solution to form a supramolecular structure through various secondary binding forces. In this study, nucleobase‐containing templates poly(9‐(4‐vinylbenzyl)adenine) (P S AH) and poly(1‐(4‐vinylbenzyl)cytosine) (P S CH) are prepared by reversible addition‐fragmentation chain transfer (RAFT) polymerization. Vinylbenzyl thymine (M S T) is polymerized in the presence of these two nucleobase‐containing templates. M S T shows higher affinities toward the template P S AH compared with the template P S CH. In accordance with the Watson–Crick pairing principle, thymine forms hydrogen bonding (H‐bonding) with adenine, but not between thymine and cytosine. A complex is formed when P S AH is used as template which indicates that there is a template polymerization of nucleobase complexes via molecular recognition.