Templated Polymerization of Nucleobase Complexes via Molecular Recognition | Zendy

Wang Mu | Zendy; Chu Fuke | Zendy; Xiao Jingjing | Zendy; Choi Bonnie | Zendy; Wei Xiaohu | Zendy; Feng Anchao | Zendy

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Templated Polymerization of Nucleobase Complexes via Molecular Recognition

Author(s) -

Wang Mu,

Chu Fuke,

Xiao Jingjing,

Choi Bonnie,

Wei Xiaohu,

Feng Anchao

Publication year - 2020

Publication title -

macromolecular rapid communications

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.348

H-Index - 154

eISSN - 1521-3927

pISSN - 1022-1336

DOI - 10.1002/marc.202000352

Subject(s) - nucleobase , thymine , polymerization , chemistry , supramolecular chemistry , chain transfer , hydrogen bond , molecular recognition , polymer chemistry , cytosine , template , base pair , stereochemistry , dna , molecule , materials science , radical polymerization , polymer , organic chemistry , nanotechnology , biochemistry

Macromolecules have a strong tendency to interact with each other in solution to form a supramolecular structure through various secondary binding forces. In this study, nucleobase‐containing templates poly(9‐(4‐vinylbenzyl)adenine) (P S AH) and poly(1‐(4‐vinylbenzyl)cytosine) (P S CH) are prepared by reversible addition‐fragmentation chain transfer (RAFT) polymerization. Vinylbenzyl thymine (M S T) is polymerized in the presence of these two nucleobase‐containing templates. M S T shows higher affinities toward the template P S AH compared with the template P S CH. In accordance with the Watson–Crick pairing principle, thymine forms hydrogen bonding (H‐bonding) with adenine, but not between thymine and cytosine. A complex is formed when P S AH is used as template which indicates that there is a template polymerization of nucleobase complexes via molecular recognition.

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