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Anisotropic Bimetallic Core–Satellite–Poly(aniline) Nanohybrids for Detection of Autoantibodies
Author(s) -
Hwang Eun Young,
Lee Jae Hee,
Lim Dong Woo
Publication year - 2020
Publication title -
macromolecular rapid communications
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.348
H-Index - 154
eISSN - 1521-3927
pISSN - 1022-1336
DOI - 10.1002/marc.202000331
Subject(s) - bimetallic strip , materials science , nanoparticle , nanotechnology , nanorod , raman scattering , nanomaterials , nanostructure , colloidal gold , biosensor , raman spectroscopy , metal , optics , physics , metallurgy
Bimetallic core–satellite nanoparticles are widely exploited in surface‐enhanced Raman scattering (SERS)‐based applications due to their enhanced optical properties compared to single‐component metallic nanoparticles (MNPs). In addition, anisotropic hybrid nanostructures containing both MNPs and polymeric compartments constitute a new class of functional nanomaterials for photonic applications because they show different functionalities and physicochemical characteristics at two distinct compartments. Herein, synthesis of two kinds of anisotropic bimetallic core–satellite–poly(aniline) nanohybrids (ABCPNs) using small or polymeric ligand‐coated gold nanospheres or gold nanorods as seeds is reported. The ABCPNs exhibit enhanced optical properties due to a local electromagnetic field generated in the narrow interparticle gap between core and satellite nanoparticles. Furthermore, a SERS‐based quantitative analysis of autoantibodies against cyclic citrullinated peptide using the ABCPNs as SERS nanoprobes for a diagnosis of early rheumatoid arthritis is demonstrated, suggesting that these multifunctional nanostructures will be potential for advanced SERS‐based biosensors.