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Photo‐Degradable Micelles Capable of Releasing of Carbon Monoxide under Visible Light Irradiation
Author(s) -
Zhang Mingyang,
Cheng Jian,
Huang Xuming,
Zhang Guoying,
Ding Shenggang,
Hu Jinming,
Qiao Ruirui
Publication year - 2020
Publication title -
macromolecular rapid communications
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.348
H-Index - 154
eISSN - 1521-3927
pISSN - 1022-1336
DOI - 10.1002/marc.202000323
Subject(s) - nanocarriers , micelle , amphiphile , carbon monoxide , copolymer , irradiation , nanoparticle , drug delivery , visible spectrum , materials science , chemistry , controlled release , photochemistry , chemical engineering , nanotechnology , organic chemistry , aqueous solution , polymer , catalysis , physics , optoelectronics , nuclear physics , engineering
Carbon monoxide (CO) has emerged as a potential therapeutic agent for the treatment of many diseases. However, the therapeutic outcome is highly dependent on the dosages and administration sites. Hence, there is mounting interest in the development of CO‐releasing materials to accomplish site‐specific and dose‐controlled delivery of CO. Herein, a micellar nanoparticle platform for the photo‐mediated release of CO by using amphiphilic triblock copolymers bearing CO‐releasing moieties of 3‐hydroxylflavone (3‐HF) derivatives within the middle blocks is developed. These micelles are relatively stable without CO leakage but undergo visible light‐mediated CO release and simultaneous main chain scission. Moreover, these micellar nanoparticles are cytocompatible regardless of light irradiation, which shows unique anti‐inflammatory performance only after light irradiation as a result of photo‐triggered CO release. This work may represent the first example of main‐chain degradable micellar nanocarriers with controlled CO‐releasing performance for potential anti‐inflammatory applications.