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Dynamic Covalent Chemistry Enables Reconfigurable All‐Polysaccharide Nanogels
Author(s) -
Abdi Fatma,
Michel Raphaël,
Poirot Robin,
Dakir Malika,
Sancey Lucie,
Ravaine Valérie,
AuzélyVelty Rachel
Publication year - 2020
Publication title -
macromolecular rapid communications
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.348
H-Index - 154
eISSN - 1521-3927
pISSN - 1022-1336
DOI - 10.1002/marc.202000213
Subject(s) - covalent bond , boronic acid , dynamic covalent chemistry , nanogel , chemistry , polymer , molecule , polysaccharide , biocompatible material , self healing hydrogels , control reconfiguration , nanotechnology , combinatorial chemistry , polymer chemistry , materials science , organic chemistry , drug delivery , supramolecular chemistry , computer science , medicine , biomedical engineering , embedded system
Dynamic covalent bonds are established upon molecular recognition of sugar derivatives by boronic acid molecules. These reversible links can be used in a cross‐linking method to fabricate polymer‐based responsive nanosystems. Herein, the design of the first dynamic nanogels made entirely of polysaccharides (PS) is reported. Based on PS chains alternately modified with phenyl boronic acid groups and sugar moieties, these colloids self‐assemble in physiological conditions and combine the biocompatible nature of their PS backbone with the reconfiguration capacities of their cross‐linking chemistry. These dynamic nanogels are easily prepared, stable for a long time, pH responsive, and efficiently internalized by cancer cells.