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Laser‐Triggered Writing and Biofunctionalization of Thiol‐Ene Networks
Author(s) -
Romano Angelo,
Angelini Angelo,
Rossegger Elisabeth,
Palmara Gianluca,
Castellino Micaela,
Frascella Francesca,
Chiappone Annalisa,
Chiadò Alessandro,
Sangermano Marco,
Schlögl Sandra,
Roppolo Ignazio
Publication year - 2020
Publication title -
macromolecular rapid communications
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.348
H-Index - 154
eISSN - 1521-3927
pISSN - 1022-1336
DOI - 10.1002/marc.202000084
Subject(s) - laser , thiol , materials science , ene reaction , alkene , chromophore , nanotechnology , optoelectronics , photochemistry , chemistry , optics , organic chemistry , catalysis , physics
The light responsivity of ortho‐nitrobenzyl esters ( o ‐NBE) is exploited to inscribe µ‐scale 2.5D patterns in thiol‐ene networks by direct laser writing. For this purpose, a multifunctional thiol and a photosensitive alkene with an o ‐NBE chromophore are cured upon visible light exposure without inducing a premature photocleavage of the o ‐NBE links. Once the network is formed, a laser beam source with a wavelength of 375 nm is used for selectively inducing the photocleavage reaction of the o ‐NBE groups. Positive tone patterns are directly inscribed onto the sample surface without the requirement of a subsequent development step (removing soluble species in an appropriate organic solvent). Along with the realization of dry‐developable micropatterns, the chemical surface composition of the exposed areas can be conveniently adjusted since different domains with a tailored content of carboxylic groups are obtained simply by modulating the laser energy dose. In a following step, those are activated and exploited as anchor points for attaching an Alexa‐546 conjugated Protein A. Thus, the laser writable thiol‐ene networks do not only provide a convenient method for the fabrication of positive tone patterns but also open future prospectives for a wide range of biosensing applications.