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Recombinant Spider Silk–Silica Hybrid Scaffolds with Drug‐Releasing Properties for Tissue Engineering Applications
Author(s) -
Kumari Sushma,
Bargel Hendrik,
Scheibel Thomas
Publication year - 2020
Publication title -
macromolecular rapid communications
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.348
H-Index - 154
eISSN - 1521-3927
pISSN - 1022-1336
DOI - 10.1002/marc.201900426
Subject(s) - spider silk , tissue engineering , drug delivery , silk , materials science , recombinant dna , polymer science , spider , self healing hydrogels , nanotechnology , polymer chemistry , chemistry , biomedical engineering , composite material , engineering , biology , biochemistry , zoology , gene
Abstract Fabricating biomaterials with antimicrobial activity to prevent the growth of detrimental microorganisms is of great scientific and practical interest. Here, composite materials comprising recombinant spider silk proteins and mesoporous silica nanoparticles (MSN) loaded with selected antibiotics and antimycotics are fabricated into films and hydrogels. The derived composite materials exhibit excellent antimicrobial properties with sustained release of antibiotics over the course of 15 days. Furthermore, antibiotics/antimycotics inclusion does not impair the cytocompatibility of the composite materials, all of which promote fibroblast cell adhesion and proliferation. Finally, processing of spider silk–MSN composite hydrogels using 3D printing is shown to enable the fabrication of patient‐specific antimicrobial implants to prevent infection in the near future.