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One‐Pot, Multicomponent Strategy for Designing Lymphoseek‐Inspired Hetero‐Glycoadjuvant@AuNPs
Author(s) -
Liu Mengjie,
Wen Ming,
Shen Shuyi,
Zhang Zhengbiao,
Chen Gaojian,
Zhang Weidong
Publication year - 2019
Publication title -
macromolecular rapid communications
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.348
H-Index - 154
eISSN - 1521-3927
pISSN - 1022-1336
DOI - 10.1002/marc.201900215
Subject(s) - adjuvant , internalization , antigen , cpg oligodeoxynucleotide , dendritic cell , immune system , chemistry , materials science , cell , immunology , medicine , biochemistry , gene expression , dna methylation , gene
Searching for vaccines (antigen and adjuvant) with easy preparation and strong T‐cell response are crucial for antitumor immunity. In this work, to design lymphoseek‐inspired vaccine possessing the abilities of promoting vaccine internalization and enhancing CD8 + T‐cell responses, a simple multicomponent strategy is successfully utilized to fabricate lymph node and dendritic cell dual‐targeting glycoadjuvant@AuNPs in one pot, where three different components, catechol‐containing glycopolymer, HAuCl 4 , and amine‐terminal CpG (CpG‐NH 2 ) can react in a single step to generate target adjuvant. It is found that hetero‐glycoadjuvant@AuNPs could increase adjuvant internalization and enhance the activation of bone‐marrow‐derived dendritic cells. Critically, lymphoseek‐inspired vaccine potentiates antigen‐specific CD8 + T‐cell immune responses.