Premium
Polyamide/PEG Blends as Biocompatible Biomaterials for the Convenient Regulation of Cell Adhesion and Growth
Author(s) -
Winnacker Malte,
Beringer Andreas J. G.,
Gronauer Thomas F.,
Güngör Hicran H.,
Reinschlüssel Leonhard,
Rieger Bernhard,
Sieber Stephan A.
Publication year - 2019
Publication title -
macromolecular rapid communications
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.348
H-Index - 154
eISSN - 1521-3927
pISSN - 1022-1336
DOI - 10.1002/marc.201900091
Subject(s) - biocompatibility , polyamide , materials science , polyethylene glycol , polymer , textile , tissue engineering , biomaterial , biocompatible material , chemical engineering , polymer science , polymer chemistry , nanotechnology , chemistry , composite material , biomedical engineering , organic chemistry , engineering , medicine , metallurgy
In addition to their established usage in textiles, commodities, and automotives, classical polyamides (nylons) are recently becoming increasingly interesting for applications in (bio)medicine. This fact relies on many prosperous properties of these polymers, which are toughness, resistance, biocompatibility, low immunogenicity, tunable biodegradability, and their similarity to natural peptides (amide bonds). Some nylon‐based medical products do already exist for wound treatment applications, implants, and biomolecule‐interacting membranes, but the systematic use of these polymers for tissue engineering is—although desired—still to be accomplished. Inspired by this, the suitability of nylon 6 and of a related biobased and more hydrophobic terpene‐derived polyamide as surfaces for the controlled interaction with HaCat cells (human keratinocytes) are investigated herein with regard to possible applications for regenerative skin replacement. The nylons are applied as neat polymers and as hydrophilized blends/composites with polyethylene glycol and confirm their excellent suitability as biomaterials.