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pH‐Responsive Polymer Nanoparticles for Drug Delivery
Author(s) -
Deirram Nayeleh,
Zhang Changhe,
Kermaniyan Sarah S.,
Johnston Angus P. R.,
Such Georgina K.
Publication year - 2019
Publication title -
macromolecular rapid communications
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.348
H-Index - 154
eISSN - 1521-3927
pISSN - 1022-1336
DOI - 10.1002/marc.201800917
Subject(s) - nanoparticle , drug delivery , polymer , nanotechnology , biophysics , chemistry , drug carrier , combinatorial chemistry , materials science , organic chemistry , biology
Stimuli‐responsive nanoparticles have the potential to improve the delivery of therapeutics to a specific cell or region within the body. There are many stimuli that have shown potential for specific release of cargo, including variation of pH, redox potential, or the presence of enzymes. pH variation has generated significant interest for the synthesis of stimuli‐responsive nanoparticles because nanoparticles are internalized into cells via vesicles that are acidified. Additionally, the tumor microenvironment is known to have a lower pH than the surrounding tissue. In this review, different strategies to design pH‐responsive nanoparticles are discussed, focusing on the use of charge‐shifting polymers, acid labile linkages, and crosslinking.